Use of Corticosteroids in the management of Idiopathic Pulmonary Haemosiderosis: Do we have enough evidence
نویسندگان
چکیده
Idiopathic Pulmonary Haemosiderosis (IPH) is a rare disease commonly affecting the paediatric population with approximately 500 globally reported cases in the literature. The disease usually presentswith a symptom triad consisting of ferropenic anaemia, cough with haemoptysis and diffuse bilateral alveolar infiltrates. Therapeutic options for this disorder are not only limited but also not fully effective. Moreover, corticosteroids remain the mainstay of IPH treatment. This communication reviews the available evidence in support of corticosteriod usage in the treatment of IPH. We conclude that the use of corticosteroid in IPH treatment is unfathomed and demands further investigation.
منابع مشابه
Idiopathic pulmonary haemosiderosis in a child with Down's syndrome: case report and review of the literature.
We report the case of a female child with Down's syndrome affected by idiopathic pulmonary haemosiderosis (IPH), who was successfully treated with hydroxychloroquine. First-line conventional treatment of IPH is traditionally based on systemic corticosteroids; however, many steroid-sparing agents are being increasingly used as adjuncts to corticosteroids in children with recurrent or refractory ...
متن کاملIdiopathic pulmonary haemosiderosis revisited.
Idiopathic pulmonary haemosiderosis is a rare cause of diffuse alveolar haemorrhage of unknown aetiology. It occurs most frequently in children, has a variable natural history with repetitive episodes of diffuse alveolar haemorrhage, and has been reported to have a high mortality. Many patients develop iron deficiency anaemia secondary to deposition of haemosiderin iron in the alveoli. Examinat...
متن کاملIdiopathic Granulomatosis Mastitis, Time to a Paradigm Change in Treatment
Idiopathic granulomatous mastitis (IGM) is among the chronic diseases of the breast, which is more common in Middle Eastern countries than in Western countries. Since the etiology of the disease is not well known, there is no international consensus on the management of the disease. Antibiotic, Non-Steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, cytotoxic and immunosuppressive medi...
متن کاملPulmonary Haemosiderosis (apparently Idiopathic) Associated with Myocarditis, with Bilateral Penetrating Corneal Ulceration, and with Diabetes Mellitus.
The literature of pulmonary haemosiderosis includes an account by Campbell and Macafee (1959) of idiopathic pulmonary haemosiderosis associated with myocarditis. Their patient first had symptoms of shortness of breath at the age of 7; he was found to have the radiological changes of pulmonary haemosiderosis at the age of 12, and he died when 14 years old. Death was due to cardiac failure, and a...
متن کاملA Case of Idiopathic Pulmonary Haemosiderosis with Myocarditis.
Idiopathic pulmonary haemosiderosis is a not uncommon condition characterized clinically by anaemia, haemoptysis, and radiological changes in the luing fields. It was first described by Ceelen (1931), and the clinical and pathological findings of the disease have been fully reviewed by Wyllie, Sheldon, Bodian and Barlow (1948). This case is presented because of the association of myocarditis wi...
متن کامل